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Can you retain polar acidic compounds using reversed-phase conditions? | Trust Your Science, S2E16

Silica-based, reversed-phase C18 columns have little-to-no retention for polar acid compounds. Is it possible to retain polar acids under reversed-phase conditions?

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53:38
WEBINAR - Elevate Your Workflow By Optimizing Durable Data and Intrinsic Compliance
WEBINAR - Elevate Your Workflow By Optimizing Durable Data and Intrinsic Compliance
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MaxPeak Premier Columns
MaxPeak Premier Columns
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Introducing CORTECS Premier Solid-Core Columns
Introducing CORTECS Premier Solid-Core Columns
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Improve Peak Shape and Peak Capacity with Advancements in Solid-Core Technology
Improve Peak Shape and Peak Capacity with Advancements in Solid-Core Technology
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Achieve High Chromatographic Efficiencies Without Lengthy Column Conditioning
Achieve High Chromatographic Efficiencies Without Lengthy Column Conditioning
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Increasing Sample Throughput Without Sacrificing Resolution
Increasing Sample Throughput Without Sacrificing Resolution
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BioAccord Community Insights | Answering Critical Biological Questions with N-Glycan Analysis
BioAccord Community Insights | Answering Critical Biological Questions with N-Glycan Analysis
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Size-Exclusion Chromatography (SEC) and Waters Part 1: Thinking Differently
Size-Exclusion Chromatography (SEC) and Waters Part 1: Thinking Differently
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Size-Exclusion Chromatography (SEC) and Waters Part 3: Designing the Next Generation
Size-Exclusion Chromatography (SEC) and Waters Part 3: Designing the Next Generation
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Size-Exclusion Chromatography (SEC) and Waters Part 2: Overcoming Challenges
Size-Exclusion Chromatography (SEC) and Waters Part 2: Overcoming Challenges
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Waters BioResolve: See What We Designed
Waters BioResolve: See What We Designed
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Phospholipid removal reduces matrix effects and improves column lifetime. It doesn't really matter which SPE sorbent I choose, as long as it retains my analyte, right? | Trust Your Science, S2E18
Phospholipid removal reduces matrix effects and improves column lifetime. It doesn't really matter which SPE sorbent I choose, as long as it retains my analyte, right? | Trust Your Science, S2E18
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Solid-core particles: lower backpressure than fully-porous particles?
Solid-core particles: lower backpressure than fully-porous particles?
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AccQ•Tag Ultra Amino Acid Kit for Automation
AccQ•Tag Ultra Amino Acid Kit for Automation
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Can you retain polar acidic compounds using reversed-phase conditions? | Trust Your Science, S2E16
Can you retain polar acidic compounds using reversed-phase conditions? | Trust Your Science, S2E16

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